Owen Farrell and Jonny May have withdrawn from the England squad through injury.
England are spending five days at a training camp in Jersey to prepare for the upcoming Autumn Nations Series – with England Rugby announcing on Monday that Farrell and May will no longer travel.
Farrell suffered a concussion in Saracens’ 22-20 Gallagher Premiership win over Exeter at the weekend, while May sustained an elbow injury as Gloucester beat London Irish 22-21 on Friday night.
Injured duo Henry Arundell and Will Stuart will still travel as they nurse foot and knee injuries, respectively.
Farrell will follow return-to-play protocols as Sale’s Tom Roebuck earns a first call-up, with Adam Radwan and Henry Slade also recalled.
Charlie Atkinson, who has recently been linked with Leicester, will join Eddie Jones’ ranks as a training player
England face Argentina, Japan, New Zealand and South Africa at Twickenham between November 6-26.
